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Timolol gel forming eye drops

Timolol Maleate Gel-Forming Solution - WebM

  1. utes before timolol gel solution. To apply eye drops, wash your hands first. To avoid conta
  2. TIMOLOL (TIM oh lol) is used in the eye to treat open-angle glaucoma and high pressure in the eye. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME (S): Timoptic-XE. Cleveland Clinic is a non-profit academic medical center
  3. g Solution. Repeated observations over a period of six months indicate that the intraocular pressure-lowering effect of Timolol Maleate Ophthalmic Gel For
  4. istered only once a day. Follow all directions given to you by your doctor carefully

Timoptol-LA Gel-Forming Eye Drops Solution bottle contains 2.5 ml of solution. Two alternative bottles may be marketed. White translucent low-density polyethylene bottle with a transparent dropper tip and a white cap. o How is this medicine (Timolol Gel Eye Drops) best taken? Use this medicine (timolol gel eye drops) as ordered by your doctor. Read all information given to you. Follow all instructions closely. For the eye only. Use as you have been told, even if your signs get better. Use this medicine (timolol gel eye drops) at the same time of day This medication is for use in the eye(s), usually one drop in the affected eye(s) once a day, or as directed by your doctor. Apply other eye medications at least 10 minutes before timolol gel solution. To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface

Timolol eye gel-forming solution - my

Each mL of Timolol Maleate Ophthalmic Gel Forming Solution 0.5% contains 5 mg of timolol (6.8 mg of timolol maleate). Inactive ingredients: gellan gum, tromethamine, mannitol, and water for injection. Preservative: benzododecinium bromide 0.012%. The gel forming solution contains a purified anionic heteropolysaccharide derived from gellan gum Timolol (Ophthalmic) This information from Lexicomp explains what you need to know about this medication, including what it's used for, how to take it, its side effects, and when to Gel-forming solution: Turn container upside down and shake once before each use. Use other eye drugs 10 minutes before the gel Timoptol-LA gel-forming eye drops contain the active ingredient timolol maleate, which is a type of medicine called a beta-blocker. It works by blocking beta-receptors in the eye, which lowers the. TIMOPTIC XE EYE DROPS (GEL FORMING SOLUTION) (TIMOLOL) Description of Timoptic XE Eye Drops . If you are found to have increased pressure in your eye or you have open-angle glaucoma, your ophthalmologist can recommend that you use Timoptic XE Eye Drops, an extended release formula with Timolol as the active ingredient Background: Timolol has been formulated in a highly purified gellan gum to improve its duration of action. The efficacy of this formulation in short-term studies using once-daily dosing has been reported. Objective: The purpose of this study was to evaluate the efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution (timolol GS) given once daily versus 0.5% timolol.

Timolol Maleate Ophthalmic: Uses, Side Effects

Timoptol-XE Gel forming eye drops - NPS MedicineWis

This medication is for use in the eye (s), usually one drop in the affected eye (s) once a day, or as directed by your doctor. Apply other eye medications at least 10 minutes before timolol gel solution. To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface Shake the regular eye drops well just before each use. If you are using the gel-forming eye drops, turn the bottle upside down and shake it one time. You do not need to shake the gel-forming eye drops more than once. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket

Manufacturer's PIL, Timoptol®-LA 0.25 and 0.5% w/v Gel-Forming Eye Drops Solution; Santen UK Limited, The electronic Medicines Compendium. Dated April 2018. Dated April 2018. Manufacturer's PIL, Tiopex® timolol 1 mg/g, eye gel in single-dose container ; Thea Pharmaceuticals Ltd, The electronic Medicines Compendium maleate gel forming ophthalmic solution)} 6.1.2 General Discussion of Endpoints Study C-01-01 was designed to describe the safety and efficacy of Betoptic S, Timolol GF The usual dose for adults is one drop of TIMOPTOL-XE once a day, in either one or both eyes. TIMOPTOL-XE contains a new delivery vehicle, gellan gum. This vehicle allows the eye drop to form a clear gel when it contacts the eye. This gel increases the contact time of timolol maleate with the eye Timoptol-LA 0.25% w/v gel-forming eye drops, solution. Timoptol-LA 0.5% w/v gel-forming eye drops, solution. timolol (as maleate) Read all of this leaflet carefully before you start using this medicine because it contains important information for you. Keep this leaflet. You may need to read it again Each of the 11 trials evaluated the efficacy of timolol versus at least one other ophthalmic beta-adrenergic antagonist. The majority of published data suggest similar 0.25%, 0.5% Solution: 0.3% Gel Forming 1‐2 drops into affected eye(s).

If you have any questions regarding the information, consult your doctor or pharmacist.This medication is for use in the eye(s), usually one drop in the affected eye(s) once a day, or as directed by your doctor.Apply other eye medications at least 10 minutes before timolol gel solution.To apply eye drops, wash your hands first Bausch Health has all Timoptic Ocumeter Plus presentations on back order and the company cannot estimate a release date. Greenstone has timolol 0.25% ophthalmic solution in 5 mL bottles on allocation. The 0.25% 10 mL bottles are on back order and the company estimates a release date of early- to mid-June 2021 Ophthalmic timolol can cause irritation to the eye which may manifest as pain or dryness in some people. Rarely, timolol eye drops can result in side effects that are seen with other oral beta adrenergic blockers. For example, persons can experience: fatigue, insomnia, nausea, slow heart rate, low blood pressure, cold extremities, and Generic Name Timolol DrugBank Accession Number DB00373 Background. Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. 16 It is also used in tablet form as a drug to treat hypertension. 17 Timolol was first approved by the FDA in 1978. 16 This drug is marketed by several manufacturers 20 and is an effective.

0.25% AND 0.5% (TIMOLOL MALEATE OPHTHALMIC SOLUTION) in. OCUDOSE. If your eyes are sensitive to the preservative benzalkonium chloride, TIMOPTIC IN OCUDOSE, a preservative-free eye drop for lowering high eye pressure, is available. It is supplied in a sterile, single-use container that should be used immediately upon opening, and then discarded When timolol maleate ophthalmic gel-forming solution is used, the usual dosage of timolol is 1 drop of a 0.25 or 0.5% solution in the affected eye(s) once daily. Because of diurnal variations in IOP, IOP should be measured at different times during the day to determine if an adequate effect is maintained in patients receiving single daily dose. Timolol gel-forming solutions may offer certain advantages. Firstly, the gel formulation allows a longer exposure of the active ingredient upon the ocular surface, and by doing so enhances ocular absorption and bioavailability. This allows a once-daily administration regimen to be sufficient TIMOLOL MALEATE-EX, 0.25% or 0.5% comes as a gel-forming solution (a liquid that thickens to a gel when instilled in the eye) to use as eye drops. It is supplied in 5 mL bottle designed to deliver a precise quantity of the medication. Do not use T-LO and TIMOLOL MALEATE-EX: if you are allergic to

Timoptol LA 0.5% w/v Gel-Forming Eye Drops Solution ..

As 0.25% or 0.5% gel-forming eye drops: Instill 1 drop into the affected eye (s) once daily. Adult: Initially, 5 mg bid for 2 days, starting w/in 1-4 wk after MI, increased to 10 mg bid if no adverse effects are observed. Adult: Initially, 10 mg/day, increased according to response every 7 or more days The only randomised, placebo-controlled trial on timolol was performed by Chan et al in infants aged 5 to 24 weeks and indicates that up to 2 drops per day of topical timolol maleate 0.5% gel for 24 weeks' duration is a safe and effective therapy for the treatment of IH not requiring systemic treatment Timolol Ophthalmic Gel Forming Solution 0.25%, 0.5% w/v (as timolol maleate) THERAPEUTIC CLASSIFICATION: Antiglaucoma Preparations and Miotics Sandoz Canada Inc. Date of Preparation: 145 Jules-Léger Street, September 26, 2017 Boucherville, QC, J4B 7K8. Eye drops Solution: Initially, instill 1 drop of 0.25% solution bid into the affected eye(s), may increase to 1 drop of 0.5% solution bid if there is inadequate response; decrease to 1 drop once daily if controlled.Do not exceed 1 drop bid of 0.5% solution. Gel-forming eye drops: 0.25% or 0.5% Gel-forming eye drops: Instill 1 drop into the affected eye(s) once daily

Timoptol-LA contains a substance called timolol which belongs to a group of medicines called beta-blockers. Timolol lowers the pressure in your eye(s). It is used to treat glaucoma, when the pressure in the eye is raised. How to take Timoptic-XE. Always use Timoptol-LA eye drops solution exactly as your doctor has told you Dosage. Timocare dosage. Eye drops Solution: Initially, instill 1 drop of 0.25% solution bid into the affected eye(s), may increase to 1 drop of 0.5% solution bid if there is inadequate response; decrease to 1 drop once daily if controlled.Do not exceed 1 drop bid of 0.5% solution. Gel-forming eye drops: 0.25% or 0.5% Gel-forming eye drops: Instill 1 drop into the affected eye(s) once daily Timoptic-XE Ophthalmic gel forming solution drug summary. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Visit cvs.com for more details Timoptol-XE gel-forming eye drops 0.5% contain timolol, a non-selective beta-adrenergic receptor blocker that in its oral form is used to treat hypertension and prevent heart attack, however, in its ophthalmic form it is used to treat glaucoma. The build up of intraocular pressure (IOP) in the eye that is seen in glaucoma is caused by a.

Generic Timolol Drops and Gel – Order for Treating

Timolol Gel Eye Drops: Indications, Side Effects, Warnings

ON TOPICAL TIMOLOL GEL-FORMING Finally, another thing to consider is the gel properties SOLUTION FOR INFANTILE HEMANGIOMAS when timolol GFS is applied to skin. The GFS solution is more viscous than regular eye drops and is designed for gel formation when the drop meets To the Editor: enzymes in tears. although timolol 0.5% ophthalmic. Timolol is available as an eye drop solution or as a gel-forming eye drop. To use the eye drop solution: 1. Wash your hands thoroughly with soap and water before using the eye drop. 2. Tilt your head slightly backwards. With the index finger, pull the lower eyelid away from the eye to form a pouch and look upward. 3 PURPOSE: To investigate the influence of 2% carteolol long-acting solution (long-acting carteolol) and 0.5% timolol gel-forming solution (timolol gel) on ocular wavefront aberrations. METHODS: Ocular aberrations were assessed in the right eye of 24 healthy volunteers at baseline and at 2, 5, 10, and 15 min after instillation of long-acting. If you are using the gel-forming eye drops, turn the bottle upside down and shake it one time. You do not need to shake the gel-forming eye drops more than once. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. To use the eye drops: Hold the dropper close to your eye with the other hand Dosage. Timolol OSL contains Timolol Maleate 0.25%. Timolol OSL Dosage: Eye drops Solution: Initially, instill 1 drop of 0.25% solution bid into the affected eye(s), may increase to 1 drop of 0.5% solution bid if there is inadequate response; decrease to 1 drop once daily if controlled.Do not exceed 1 drop bid of 0.5% solution. Gel-forming eye drops: 0.25% or 0.5% Gel-forming eye drops.

Timolol Images and Labels - GoodRx

Timolol 0.5 % Gel Forming Sol - HealthWarehous

  1. g Eye Drops Solution. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION. Each millilitre of 0.5% w/v solution contains an amount of timolol maleate equivalent to 5 mg/ml timolol. 3 PHARMACEUTICAL FORM. Sterile gel-for
  2. utes after using this medicine before putting in your contact lenses. Wash your hands before using the eye drops. To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket
  3. g Solution TIMOPTOL-XE® 0.5% Ophthalmic Gel For

Timolol maleate 0.5% versus timolol maleate in gel forming ..

  1. The preservative is known to discolour soft contact lenses. Always use Timolol exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The usual starting dose is one drop of 0.25% eye drops into each affected eye(s) twice daily, approximately 12 hours apart
  2. g Solution. Generic Drug Code. 32823. Generic Drug Name. Timolol Maleate. NDC Number. 61314-0225-05. Product Dating. McKesson Acceptable Dating: we will ship >= 90 days
  3. g Eye Solution. Timolol maleate gel is used commonly to treat glaucoma. Glaucoma is caused by a build-up of pressure in the eye often due to increased fluid. Fluid can become trapped in the eye and not drained properly. Timolol maleate gel is used to reduce the pressure in the eye
  4. g a hydrogel and thus changed the rheology property
  5. g eye drops [Merck Sharp & Dohme] Presentation Timolol maleate 0.5% (5 mg/mL) ophthalmic solution/gel. Dosage/Interva
  6. g solution (GFS) once daily with 0.5% timolol maleate ophthalmic solution twice daily in patients with open-angle glaucoma. In both treatment groups (30 eyes each), IOP was measured at baseline and weeks 2, 4, 8, 12, and 24. The mean decrease of IOP at trough ranged from 5.5 to 5.9 mm Hg for.
  7. and dryness and now smoking outdoors. ? is...can I use Timolol gel eye drops until I can see a Dr. on Monday the timolol eye drops until I see a my dr. on monday I have a server eye irritation , my eyes are itchy, red.
Timolol Maleate - patient information, description, dosage

Timoptic-XE (Timolol Maleate Ophthalmic Gel Forming

Gel-forming eye drops: 0.25% or 0.5% Gel-forming eye drops: Instill 1 drop into the affected eye(s) once daily. Interaction Although Timolol used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with Timolol Maleate and epinephrine has been reported occasionally The goal of this study was to develop and characterize an ion-activated in situ gel-forming estradiol (E2) solution eye drops intended for the prevention of age-related cataracts. Accordingly, in situ gelling eye drops were made using gellan gum as an ion-activated gel-forming polymer, polysorbate-80 as drug solubilizing agent, mannitol as tonicity agent, and combination of potassium sorbate. The prevalence of glaucoma increases with age.1 Timolol, a non-selective β blocker, is the first line treatment. We present three cases from our falls clinic, in which we show that even a low dose of timolol eye drops may cause severe systemic adverse effects. ### Case 1 A 73 year old man was referred by his general practitioner because he had been unconscious for half an hour the previous day Mäenpää J, Volotinen-Maja M, Kautiainen H, et al. Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops. Drug Metab Dispos. 2014;42(12):2068-2076. 65. Pilocarpin Puroptal ®, 2% - Augentropfen (pilocarpin). Austria.

While eye drops are the most common ocular dosage form, eye drops for treating diseases of the posterior segment (retina, choroid, optic nerve) have yet to be developed. In glaucoma, eye drops are used extensively for delivering intraocular pressure (IOP)-lowering medications to the anterior segment. However, degeneration of retinal ganglion cells (RGCs) in the retina may progress despite. used as an ophthalmic vehicle for pilocarpine delivery and found that the gel formation enhances the activity of pilocarpine. Timolol maleate form thermo gelling drug delivery system composed of cellulose ether ethylhydroxylethylcellulose13. The effect of flurbiprofen, a non steroidal anti inflammatory drug, formulated i Timoptol-LA gel-membentuk tetes mata mengandung bahan aktif timolol maleat, yang merupakan jenis obat yang disebut beta-blocker. Ia bekerja dengan memblokir reseptor beta di mata, yang menurunkan tekanan cairan di dalam bola mata Eye drops used in managing glaucoma decrease eye pressure by helping the eye's fluid to drain better and/or decreasing the amount of fluid made by the eye. Drugs to treat glaucoma are classified by their active ingredient. Timolol maleate ophthalmic gel forming solution 0.25%, 0.5%: Novartis: Betoptic® S: Betaxolol HCI 0.25%, 0.5%

eye(s) twice daily Timolol 0.5% gel-forming solution Timolol 0.5% solution instill 1 drop into affected eye(s) twice daily Others Brimonidine 0.1% solution Brimonidine 0.2% solution at the same dose and Brimonidine 0.15% solution frequency Brimonidine and timolol 0.2%/0.5% solution Brimonidine 0.2% solution instill 1 drop int 5mg/ml timolol maleate eye drop SmPC ®-LA 0.25% 2.5mg/ml timolol maleate gel forming eye drop SmPC Timoptol® -LA 0.5% 5mg/ml timolol maleate gel forming eye drop SmPC TRUSOPT® 20mg/ml dorzolamide eye drops SmPC If you are interested in more information about this product please call: 0345 075 4863 or email: medinfo@santen.co.u Timoptol®-LA 0.25% w/v Gel-Forming Eye Drops Solution Timoptol®-LA 0.5% w/v Gel-Forming Eye Drops Solution. timolol (as maleate) Read all of this leaflet carefully before you start using this medicine. - Keep this leaflet. You may need to read it again. - If you have any further questions, ask your doctor or pharmacist

Timolol (Ophthalmic Route) Side Effects - Mayo Clini

TIMOLOL MALEATE Savings, Coupons and Information. | TIMOLOL (TYE moe lole) is used in the eye to treat open-angle glaucoma and high pressure in the eye. Introduction . Ophthalmic timolol, a topical nonselective beta-blocker, has the potential to be absorbed systemically which may cause adverse cardiovascular effects. This study was conducted to determine whether initiation of ophthalmic timolol was associated with an increased risk of hospitalisation for bradycardia. Materials and Methods Timolol (0.5%) gel in BID dosage was used in a 3-year-old child and the resolution was noted after 6 months. Oke et al. also demonstrated successful treatment with timolol (0.5% BID, gel/solution) in four pediatric cases. DeMaria et al. noted the efficacy of topical timolol in the largest study till date involving 17 patients. Treatment was.

Timolol maleate ophthalmic gel forming solution is indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Aton will continue to. eye drops on the cardiovascular and respiratory systems (MAENPAA and PELKONEN, 2016). In order to overcome the limitations related to the administration of eye drops, recent studies have developed a new formulation of timolol maleate in gel form, which should ensure the better permeability of the drug. the new formulation in gel form should prolon 2.5mg/ml timolol maleate gel forming eye drop Timoptol® -LA 0.5% 5mg/ml timolol maleate 5mg/ml timolol maleate eye drops SANTEN UK PRODUCT PORTFOLIO.

Timolol (Ophthalmic Route) Proper Use - Mayo Clini

Plasma timolol concentrations of timolol maleate: timolol gel-forming solution (TIMOPTIC-XE) once daily versus timolol maleate ophthalmic solution twice daily. Documenta Ophthalmol 2001; 103 (1. Timolol is available as an eye drop solution and a gel-forming eye drop. Follow these steps: 1. Wash your hands thoroughly with soap and water before applying the eye drop. 2. Tilt your head slightly backwards and look upwards. 3. Use your finger to gently pull the lower eyelid down. 4. Apply the required number of drops inside the lower eyelid. 5

Timolol (Into the eye) Timolol (TIM-oh-lol) Treats glaucoma. This medicine is a beta-blocker. You do not need to shake the gel-forming eye drops more than once. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket Timoptol-LA gel-forming eye drops. Tiopex eye gel. Timolol eye drops are also available without a brand name, ie as the generic medicine. Further reading

Timolol GFS - FDA prescribing information, side effects

We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate 0.5% . Our hypothesis is that timolol will inhibit and possibly reverse growth of appropriate infantile hemangiomas Timolol is a prescription beta blocker used to treat glaucoma or migraines and to lower the risk of repeat heart attacks. It may be prescribed as tablets, eye drops, or extended release gel-forming eye drops. Timolol is classified as a beta blocker. Beta blockers reduce blood pressure by blocking the effects of adrenaline in the body

DailyMed - TIMOLOL MALEATE OPHTHALMIC GEL FORMING SOLUTION

Timolol Maleate is a prescription medication used to decrease pressure in the eye. It's frequently used in cases of glaucoma to reduce intraocular pressure. This safe and effective formula comes as drops to be applied directly in the eyes Dorzolamide hydrochloride ophthalmic solution and dorzolamide hydrochloride-timolol maleate ophthalmic solution, two glaucoma medications, are both listed as currently in shortages by the FDA and. the timolol eye drops until I see a my dr. on monday I have a server eye irritation , my eyes are itchy, red and dryness and now smoking outdoors. ? is...can I use Timolol gel eye drops until I can see a Dr. on Monday. square technique to receive placebo twice daily, 0.5% timolol solution twice daily, or 0.5% timolol gel once a day (placebo given as second dose) to each eye for 2 weeks. Subjects then were crossed over to the two other treatments for 2-week treatment intervals. At each visit, patients were received a dose 15 minutes before pulmonary function testing. Results This study began with 25 patients.

Like propranolol, timolol maleate is a nonselective beta blocker, and it is commonly used to treat infantile glaucoma, Dr. Chambers said. A 0.5% solution and a 0.5% gel have been shown to be. 2- 7 Timolol maleate is a nonselective β-blocker readily available as an ophthalmic preparation as both a solution and gel-forming solution (GFS). It has been used for >3 decades in pediatric patients and is approved by the US Food and Drug Administration for the treatment of elevated intraocular pressure in children aged <6 years Timolol. Timolol is a medication used either by mouth or as eye drops. As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma. Timolol is a non-selective beta blocker

Gotas Para Glaucoma Timolol - Astigmatism Glaucoma SwollenTimoptic Xe Images and Labels - GoodRx

FDA Drug Shortage

timolol maleate: SOLUTION, GEL FORMING/DROPS;OPHTHALMIC: 020330-002: Nov 4, 1993 Free Forever Trial Free Forever Trial: Sandoz Inc: TIMOLOL MALEATE: timolol maleate: SOLUTION, GEL FORMING/DROPS;OPHTHALMIC: 020963-001: Oct 21, 1998 Free Forever Trial Free Forever Trial: Bausch And Lomb: ISTALOL: timolol maleate: SOLUTION/DROPS;OPHTHALMIC: 021516. Timolol is a beta blocker medication used either by mouth or as eye drops. As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma. By mouth it is used for high blood pressure, chest pain due to insufficient blood flow to the heart, to prevent further complications after a heart attack, and to prevent migraines There are several generic Timoptic (timolol) products available on the market at this time. Both the regular solution and the gel-forming drops come in a 0.25 percent and 0.5 percent strength. All of the generic versions currently available have an AT or AB rating, meaning they should be equivalent to the brand-name versions Drug Name Generic Name : timolol maleate Brand Name: Apo-Timol (CAN), Apo-Timop (CAN), Betimol, Blocadren, Gen-Timolol (CAN), Novo-Timol (CAN), Nu-Timolol (CAN), Timoptic, Timoptic-XE Classification: Beta-adrenergic blocker, Antihypertensive, Antiglaucoma drug Pregnancy Category C Dosage & Route Available forms : Tablets—5, 10, 20 mg; ophthalmic solution, gel—0.25%, 0.5% ADULTS Oral.

Medicine information - Kaiser PermanenteOur Products - Aromed Pharmaceuticals | Eye Drops

• Timoptol (timolol) LA 0.25% w/v gel-forming eye drops, solution • Timoptol (timolol) LA 0.5% w/v gel-forming eye drops, solution • The new bottles will be introduced for these products between August 2019 and February 2020 • Patients should be advised that administration instructions have changed for their products - these can be. This can present a problem in instances where these groups need to exchange information, collaborate, or ensure that legislated timolol eye drops 0.5 preservative free requirements or international agreements are adhered to. psychological ailments If you are making use of Elimite simply once, you timololo gel will probably not obtain such COMBIGAN ® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% Important Information . INDICATION AND USAGE COMBIGAN ® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular.