Lipoma vs. Liposarcoma Center Both lipoma (benign) and liposarcoma (malignant) form in fatty tissue While both lipoma and liposarcoma form in fatty tissue and can cause lumps, the biggest difference between these two conditions is that lipoma is benign (noncancerous) and liposarcoma is malignant (cancerous) Well-differentiated liposarcoma and atypical lipoma are pathologic synonyms because they are identical lesions both morphologically and karyotypically . They represent the lowest grade lesions in the spectrum of liposarcoma. Infiltrative intramuscular lipomas are the exception to this description of lipoma Infiltrative lipomas (infiltrative tumors) This is a relatively uncommon tumor that is differentiated from simple lipoma or liposarcoma by cytology or biopsy. They are considered benign (noncancerous) and do not metastasize (spread) to distant organs, however, they can invade immediately adjacent tissues such as muscle, joint capsule or even bone The differential diagnosis between intramuscular, infiltrating lipoma and well-differentiated liposarcoma is difficult especially when the tumor is large and deep seated. Increased age, male gender, and large tumor size (>10 cm) were reported as the risk factors of malignancy. 9 However, in our series, the tumor size varied, and increased age.
Well-differentiated liposarcoma is a slow growing, infiltrative, and nonmetastasizing neoplasm that is microscopically and diagnostically challenging. It can be reliably separated from a benign spindle cell or an atypical lipoma by using the markers MDM2 and Ki-67 Large lipomas may be appreciated as a region of low density exerting mass effect. Calcification may be present in up to 11% of cases, although more commonly associated with well-differentiated liposarcoma 5. Ultrasound. Lipomas appear as soft variably echogenic masses, commonly encountered on ultrasound TYPICAL GROSS FINDINGS: Lipoma. · Well-circumscribed, soft, white to yellow neoplasms not attached to adjacent tissue. Infiltrative Lipoma. · Soft, poorly circumscribed, deep subcutaneous masses attached to the surrounding tissue; may cause pain or interfere with limb function. Liposarcoma. · Poorly circumscribed, firm, gray-white neoplasms
Liposarcoma is a malignant tumor that arises from deep soft tissue fat.; What triggers the development of liposarcoma is unknown. Liposarcoma risk factors may include radiation, family cancer syndromes, a damaged lymph system, and/or exposure to certain chemicals.; Liposarcomas do not develop from common lipomas (benign tumors of fat cells) Lipoma Vs Liposarcoma. Lipoma refers to an adipose tumor or a type of tumor comprising of fatty tissue. These are almost always benign (non-cancerous) and are most frequently found to arise in the subcutaneous tissues although they may also be observed in other deeper tissue regions like the abdominal organs or the intermuscular septa They may grow in between layers of muscle or may grow in a location that causes your pet discomfort whenever they walk. When these tumors grow in between muscle layers, they are typically called infiltrative lipomas. The malignant form of this tumor is called a liposarcoma. These tumors tend not to spread to other places
Occasionally, a nonencapsulated lipoma infiltrates into muscle, in which case it is referred to as an infiltrating lipoma.5, 11, 12 Four other types of lipomas may be noted on a biopsy specimen It is important that both pathologists and surgeons appreciate the significant tendency of infiltrative intramuscular lipomas to recur. Hence, preventative surgical measures may be undertaken and worries that the lesion may be sarcomatous can be avoided. Differential diagnosis, most importantly from well-differentiated liposarcoma, is discussed Introduction. Intramuscular lipoma is a very rare form of lipoma, known to be categorized as an infiltrating lipoma due to its tendencies to infiltrate the muscle or the synovium. Contrary to other subcutaneous lipomas, even after surgical removal, the rate of local recurrence ranges at a high rate from 50∼80% and differential diagnosis with liposarcoma is very difficult. <i>Patients and. Introduction. Soft-tissue lipomas are the most common type of benign mesenchymal tumours made up of mature adipose tissue [1, 2].These tumours can occur at any age, but are most common in the fifth or sixth decade of life, and are multiple in 5% of patients [3, 4], often associated with a period of weight gain.They tend to stabilize in size after an initial period of steady growth Spindle Cell Lipoma Atypical Spindle Cell Lipomatous Tumor; Restricted to back of neck, upper back, shoulders : Various locations : Bland spindle cells : Mild to moderate atypia of spindle cells : Ropy collagen bundles : No ropy collagen : Circumscribed: May be infiltrative: Uniformly strong CD34 : CD34 only 5% reactive: Rb loss in all cases.
Lipoma vs. Liposarcoma: Size, cellular features and tissue invasiveness differentiate lipomas from liposarcomas; Renal mesenchymal tumor: Generally in young rats (12 months old) and do not contain lipid Fatty infiltration: Mature adipocytes with infiltrative pattern, may be difficult to differentiate from renal lipoma; COMPARATIVE PATHOLOGY Intramuscular lipoma may recur if incompletely excised. Rare large intramuscular lipomas have recurred with features of atypical lipomatous tumor. Genetic study for MDM2 amplification may be indicated in large or aggressively recurring intramuscular lipomas even in the absence of atypia. Atypical lipomatous tumor can occur in these locations Angiolipoma is a rare type of lipoma — a growth made of fat and blood vessels that develops under your skin. Between 5 and 17 percent of lipomas are angiolipomas, according to one 2016 report.
Infiltrating Lipoma (Lipoma infiltrates muscle) Angiolipoma (painful Lipomas with numerous vessels) Pleomorphic lipoma (multinucleated giant cells) Spindle cell lipoma (intermixed spindle cells) Adenolipoma (intermixed eccrine Sweat Glands) Liposarcoma (rare malignant lesion similar to Lipoma) Located in Retroperitoneum, Shoulders, and legs. . Introduction: The spermatic cord sarcomas are rare entities, with only 46 cases reported in the last 5 years worldwide. The majority of those were misdiagnosed as inguinal hernias and treated with hernioplasty, delaying the correct treatment Although the mass appeared to represent a lipoma by imaging characteristics, the unusual extension into the coronary sinus led to consideration of a low-grade liposarcoma in the differential. Thus a pre-operative biopsy was performed along with MDM2 gene amplification to rule out a liposarcoma preceding surgical excision Lipoma mainly occurs under the skin and the limbs. As long as there is fat, it is easy to grow lipoma. It is difficult to distinguish the lipoma from the normal tissue, and the texture of the lipoma is soft. Liposarcoma is a malignant soft tissue sarcoma. Liposarcoma can be easily separated from normal tissue, and it grows very fast infiltrative lipoma than those ofother described fatty tumors or fat accumulations. Lipoma and liposarcoma are the commonly recognized neoplasms offat cells [8, 10, 11]. The infiltrative nature and high recurrence rate remove the infiltrative lipoma from the category ofsimple lipoma; and the benign appearance ofthe neoplastic fa
. Every once in a great while, a fatty tumor turns out to be an infiltrative liposarcoma rather than a lipoma. These are the malignant black sheep of the fatty tumor family. Your veterinarian will be suspicious of an infiltrative liposarcoma if the fine needle aspirate cytology reveals fat cells, yet the tumor. vs Lipoma, Who Needs a Surgical Oncologist? Sarah B Fisher, MD1, benign lipoma from the aggressive liposarcoma, the nuances between large lipomas and can be poorly circumscribed and infiltrative—similar to well-differentiated liposarcomas (WDLS). (1) Histologically, lipomas may exhibit inflammatio
Liposarcoma is a rare type of cancer that begins in the fat cells. Liposarcoma is considered a type of soft tissue sarcoma. Liposarcoma can occur in fat cells in any part of the body, but most cases occur in the muscles of the limbs or in the abdomen. Liposarcoma occurs most often in older adults, though it can occur at any age The final histopathological diagnosis was well-differentiated liposarcoma with pulmonary, splenic, hepatic and lymph node metastasis. DISCUSSION Lipomas, infiltrative lipomas and liposarcomas are neoplasms of lipocytes and lipoblasts (Bevier and Goldschmidt, 1981; McChesney et al., 1980) Well-differentiated liposarcoma is a low-grade neoplasm with five histologic variants: lipoma-like, sclerosing, inflammatory, spindle cell, and liposarcoma with meningothelial whorls (which may indicate early dedifferentiation) (, 2 17-, 24). Only the first two types—lipoma-like and sclerosing—are common, and many pathologists do not. There is a malignant version of a fatty tumor called liposarcoma but that is a rare form of cancer. Generally, the cells would look more aggressive when cytology is performed which would tip the vet off that a malignant process is present. There is also a rare, somewhat strange version of a fatty tumor called infiltrative lipoma Intramuscular lipomas can be divided into two sub-groups: the infiltrative type and the well-circumscribed type. The infiltrative type is the more common of the two . A lipoma of greater than 5 cm is classified as a giant lipoma. Larger lipomas may present with functional deficit or neurovascular compromise due to mass effect
Liposarcoma (LPS) is a histologically diverse group of tumors arising from mesenchymal cells.LPS accounts for 20-25% of adult soft-tissue sarcomas, and the peak age of onset is in the fifth to seventh decades [1-3].The clinical behavior of LPS ranges from indolent nonmetastasizing disease to aggressive subtypes that can recur and metastasize rapidly Infiltrating lipomas are rare benign, slow-growing tumours. They characteristically infiltrate skeletal muscle and have a propensity for local recurrence if incompletely resected. We present a patient in whom preoperative magnetic resonance imaging (MRI) was predictive of an infiltrating lipoma of the neck. Complete resection of the lipoma was undertaken leading to resolution of symptoms Infiltrative lipoma Vs. liposarcoma. Infiltrative lipoma: rare, dogs, usu in muscles Liposarcoma: rare, dogs, metastatic both = malignant. Hemangiopericytoma: Animals effected, malignancy, site =grow AROUND BV-older dogs -site = limbs -Benign, slow growth but infiltrative The tumour can be badly limited, even infiltrative however a benign intramuscular lipoma might be very infiltrative and a well-circumscribed tumor does not eliminate a LPS [1, 5]. Actually, a fat tumor should be considered as a liposarcoma until proved otherwise when it features septums of more than 2 mm thick and nodules or not fatty areas [ 14 ] Figure 6: Complete en bloc excision of a lipoma-like well-differentiated liposarcoma of the anterior thigh. Cytogenetics On cytogenetic grounds, approximately 80% of well-differentiated liposarcomas are characterized by the presence of a supernumerary ring and/or long marker chromosomes
Soft Tissue Tumors Prepared by Kurt Schaberg Adipocytic Lipoma Specific types: Angiolipoma—Fat + prominent branching network of vessels, often with fibrin thrombi. Usu. Tender nodule on forearm. Spindle Cell Lipoma—Fat + bland spindle cells with a variably myxoid background . Infiltration of skeletal muscle is common. Most patients present with a mass or because of pain, and some patients experience some functional disability. Mot patients are less than 40 years of age, with the majority of those. Similar to infiltrative lipomas, surgical removal or debulking of the mass is the treatment of choice. Dogs who are diagnosed with liposarcoma by excisional biopsy but do not have the mass removed live an average of 183 days, or about six months Dercum disease is also known as adiposis dolorosa. It is a rare disease characterised by a combination of features: Multiple encapsulated fat overgrowths ( lipomas) on the trunk and limbs. Painful subcutaneous plaques. Ecchymoses (bruises) without noticed trauma Infiltrative lipoma is an extremely rare variant of lipoma, as only two cases of infiltrative lipoma have been reported in calves (Di et al., 2002; Sickinger et al., 2009 ). The objective of this report was to describe the clinical and histhopathological characteristics of a unique case of congenital infiltrative subcutaneous lipoma and lingual.
Cardiac lipomas are rare benign tumors of the heart. They are usually asymptomatic and are thus most often diagnosed on autopsies. Symptoms, when present, depend upon the location within the heart. Typical locations are the endocardium of the right atrium and the left ventricle. Diagnostic modality of choice is cardiac MRI. Treatment guidelines have not yet been established due to the very low. from pre-existing lipomas or infiltrative lipomas. The fa- vored sites for a liposarcoma in human beings are the deeper soft tissues, including gluteal region, the thigh, lower extrem- ity, and retroperitoneum. In the dog, there is a predilection for subcutis and deeper soft tissue involvement, yet the tho
Cardiac lipoma is an uncommon primary cardiac tumor. With the advancement of diagnostic methods and treatment techniques, more cases of cardiac lipomas have been reported and suggest that the entity previously widely thought to display classic features may also show atypical findings. A systemic review of the rare cardiac tumor was done by searching the literature of cardiac lipoma Introduction. T he current World Health Organization (WHO) classification of mesenchymal skin and soft tissue tumors of domestic animals recognizes three benign forms of tumors of the adipose tissue, represented by lipoma, infiltrative lipoma and angiolipoma, and one malignant form, represented by liposarcoma. 1 Lipomas are tumors characterized by well-differentiated adipocytes that are common.
Lipoma is the most frequent benign soft-tissue tumor. It originates from fat cells. According to position, it is distinguished in superficial, typically subcutaneous lipoma, or deep, such as intramuscular lipoma. This latter form is infrequently and may resemble well-differentiated liposarcoma. For this reason, early radiological detection and. In addition, lipoblasts are found in liposarcoma but are absent in lipoma. Lipomas may have focal or substantial basophilic mucopolysaccharide but the delicate vascular networks of myxoid liposarcoma are not represented. Intramuscular (infiltrating) lipoma lacks the multiple muscle involvement of a pediatric lipoblastoma
Location of lipoma versus liposarcoma. Lipoma: proximal extremities and trunk Liposarcoma: retroperitoneum, proximal lower extremities. Lipoma - benign tumor of adipocytes. Large palpable mass that is circumscribed or infiltrative - necrosis is uncommon unless high grade. Liposarcoma, 5th - 6th decade, malignant tumor of adipocytes Liposarcoma is a type of cancer that most often develops from fat cells. It is most commonly found in your legs or thighs, but it can also be found in your abdomen, back, arms, chest, and neck. Liposarcomas most often occur in people between the ages of 50 to 70 years old In an extreme form, although very uncommon, there is a form of the infiltrative lipoma called a liposarcoma which is a form of cancer, although it would be rare for it to metastasize. This latter tumour may require radiation, as well as surgery to keep under control. It is important to remember, though, that the vast majority of lipomas are not. It is important that both pathologists and surgeons appreciate the significant tendency of infiltrative intramuscular lipomas to recur. Hence, preventative surgical measures may be undertaken and worries that the lesion may be sarcomatous can be avoided. Differential diagnosis, most importantly from well‐differentiated liposarcoma, is discussed
Fatty tumors, called lipomas, are firm, movable growths that develop under a dog's skin. At times, these tumors become invasive, developing into infiltrative lipomas. Both types of lipomas are benign, differing from the malignant liposarcoma. A needle biopsy is required to tell the difference between benign and. . In addition to the imaging appearance, the location of the lesion and the patient demographics can be utilized to help diagnose other soft tissue lipomatous lesions, such as elastofibroma dorsi. Yoshiyama A, Morii T, Tajima T, Aoyagi T, Honya K, Mochizuki K, et al. D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma. Anticancer Res . 2014 Sep. Myxoid liposarcoma Briefly, myxoid liposarcoma tends to affect young adults and is usually deep seated, with a predilection for the thigh and polpliteal fossa. It is a well-circumscribed tumor characterized by branching thin-walled capillaries ( chicken wire or crow's feet pattern)
Diagnosis. To diagnose a lipoma, your doctor may perform: A physical exam. A tissue sample removal (biopsy) for lab examination. An X-ray or other imaging test, such as an MRI or CT scan, if the lipoma is large, has unusual features or appears to be deeper than the fatty. There's a very small chance that a lump resembling a lipoma may actually. Giant lipoma thigh. Musik-Downloads für Smartphone und Player. Mit Autorip gratis bei jedem CD-Kauf Because of the excessive size, giant lipomas may cause functional limitations, such as lymphedema, pain syndromes or nerve compression.Because of the peculiarity of this condition, the great size of the lesion and the difficulties in its diagnosis and treatment, we reported a case of a giant. liposarcoma. Hietanen et al. (1986) reported no signifi-cant differences in the fatty acid content of lipoma compared with healthy tissue, but a marked increase in the relative amounts of unsaturated fatty acids, especially arachidonic acid, and a decrease in satu-rated fatty acids in mammary cancers compared with healthy reference tissue or. diagnosis. Particularly, the differentiation of well-differentiated liposarcoma from benign lipoma is frequently recognised as a diagnostic dilemma. Lipoma Lipoma is a benign mesenchymal tumor whereby the lesion closely resembles normal fat. Simple lipomas are generally homogeneously fatty contents, and may contain a few thin Lipoma • Most common soft tissue tumor (50%) • Benign neoplasm vs. local hyperplasia of fat cells • Superficial -Upper back, neck, proximal extremities, abdomen -< 5 cm • Deep -Intra vs. Intermuscular (arbitrary) (if both = infiltratng) Murphey MD, et al. Benign Musculoskeletal Lipomatous Lesions. Radiographics 2004; 24: 1433-146
Adipose (Lipoma) Tumors. Lipomas are benign tumors of fat seen in middle-aged to older animals. Sometimes these tumors grow in between muscle layers are called infiltrative lipomas. Lipomas are benign and do not typically behave aggressively. Liposarcomas are the malignant form of the disease Liposarcoma is an uncommon type of tumorous cancer that develops in primarily older dogs. This type of cancer is quite a bit less commonly seen than many other forms. Nonetheless, it's a good idea to know what the various symptoms and warning signs of liposarcoma are, so that you'll better be able to recognize this condition if it should arise Figure. Multimodality images demonstrating left ventricular infiltrating lipoma.A, The x-ray indicated an enlarged heart.B, The mass in the left ventricle (LV) by echocardiography in parasternal long-axis view.C, The masses at the intracardiac and extracardiac site of LV in apex four-chamber view.D, Contrast-enhanced echocardiography revealed a filling defect in the epicardial and endocardial. 1. Look for a small bump under the skin. Lipomas generally appear as dome-shaped lumps that can range in size, usually between the size of a pea and roughly 3 centimetres (1.2 in) in length. If you have a lump under the skin on your body this size, it may be a lipoma Lipoma Spindle cell lipoma/Pleomorphic lipoma Well differentiated liposarcoma/Atypical lipomatous tumor Pleomorphic liposarcoma Dedifferentiated liposarcoma Bottom two entities can morphologically enter the pleomorphic or spindle cell categories 35 year old male with numerous subcutaneous masses, this from forearm Lipoma
Lipoma Liposarcoma Radiologists correctly call nearly all liposarcomas Over-call many atypical lipoma as liposarcoma (fat necrosis, calcification, myxoid tissue within lipoma) Relevant since biopsy often uncertain Lee YM et al JCAT 2011 Lipoma vs liposarcoma A liposarcoma is a lump or bump that is very similar in appearance to a lipoma, and they often appear in the same areas of the body. Liposarcomas can also develop internally, however, and may also appear around the abdominal cavity, other internal organs, and the joints. Liposarcomas are malignant, or cancerous, and prone to spreading and. vs. squamous cell carcinoma, fibroadenoma vs. infiltrating ductal carcinoma and lipoma vs. liposarcoma. Several fine individual nuclear morphological parameters were compared between two members of each set within 3 categories. Results: For squamous cell carcinomas, high N/C ratio, hyperchromasia, irregular chromatin clearing, irregular nuclea An intramuscular lipoma consists of a fatty tumor developing within the muscle fibers. To compare, an intermuscular lipoma develops between muscle groups. The type of tumor is identical in both cases. Surgical removal of an intramuscular lipoma can be a complicated procedure. The tumor presents as a bump, sometimes causing the skin to protrude
Liposarcoma. Liposarcoma is the second most common soft tissue sarcoma, accounting for 17% of soft tissue sarcomas. Liposarcoma has a 1.2:1 male predominance and occurs most commonly in the fifth to sixth decade of life. Though liposarcoma most commonly occurs in the lower extremities, it occurs in the upper extremities in roughly 7% of cases. 1 Lipomas of the PPS are rare and liposarcomas rarer still. Only 5 liposarcomas of the PPS have been previously reported ( Table ). We describe our experience at the University of South Florida (USF), Tampa, with this unusual entity in this review of 2 lipomas, 1 pleomorphic liposarcoma, and 1 dedifferentiated liposarcoma of the PPS Infiltrative liposarcoma vs lipoma. (thebark.com) Lesions 10. Lipomas are benign lesions composed of adipose tissue typically found in the integument, gastrointestinal tract, or central nervous system. (thefreelibrary.com Lipoma. Lipoma - infiltrative. Lipoma - intermuscular. Liposarcoma. Localized histiocytic sarcoma. Lymphangioma and lymphangiosarcoma. Lymphoma. Lymphoma - cranial mediastinum. Lymphoma - skin. Lymphoma - small intestine + M. Malignant histiocytosis. Malignant mesenchymoma. Mast cell tumor. Mast cell tumor - digit. Mast cell tumor - skin. Mast.
The main subdivisions of this group are intramuscular and intermuscular lipoma, lipoma of the tendon sheath, neural fibrolipoma with and without macrodactyly (fibrolipomatous hamartoma), and lumbosacral lipoma. 3. Infiltrating or diffuse neoplastic or nonneoplastic proliferations of mature fat may cause compression of vital structures or may be. A subcutaneous lipoma will generally move a bit beneath the skin if you gently press on it. Most lipomas are not generally painful to the dog, although some, called infiltrative lipomas, grow into muscles or surrounding tissue, and can be uncomfortable. A rare type of fatty tumor called a liposarcoma is malignant, meaning without treatment it. Clinical diagnostic considerations included a facial lipoma versus parotid cyst. the authors pointed out that spindle cell lipoma can be distinguished from spindle cell liposarcoma by abundant normal fat cells, extremely bland palisaded spindle cells, eosinophilic refractile collagen bundles, and the absence of an infiltrative pattern in. infiltrating lipoma, lipomatous hamartoma of atrioventricular valve, and lipoma-tous hypertrophy of interatrial septum. Solitary lipoma and atrial septal lipomatous hypertrophy are relatively common, while the other 2 are very rare. The cardiac infiltrating lipoma is a tumor that extends into the myocardium
However, one type of lipoma, the infiltrative lipoma, can require a more complex procedure. As the name implies, infiltrative lipomas invade into muscle tissue and fascia and can make complete surgical excision difficult. Radiation therapy has been used for infiltrative lipomas and may be used alone, or in conjunction with surgical excision Background. Lipomas are the most common mesenchymal tumour and are composed of mature adipocytes. 1 Liposarcomas are the most common type of soft tissue sarcoma, accounting for 20% of all types. 2-4 Lipomas arise in superficial and deep soft tissue compartments while WDL has a predilection for deep sub-fascial tissues. 5 WDL is the most common histological subtype, comprising 40-50% of all. Rarely, an infiltrative pattern may be encountered. Histologically, ALT can be divided into three subtypes: lipoma-like, sclerosing, and inflammatory. The lipoma-like ALT is composed predominantly of mature fat, which in contrast to the fat of a benign lipoma demonstrates variation in cell size
Malignant transformation of a benign lipoma to malignant liposarcoma is practically unknown.8 It is crucial that the diagnosis of a well-differentiated liposarcoma is established preoperatively, because there are differences in initial treatment, longterm management and prognosis The objective of this study was to describe the sonographic features of deep-seated lipomas. A retrospective review of the sonographic features of 64 deep seated lipomas in 64 patients (43 females, 21 males, mean age 46.5, range 16-77 years) seen over an 8-year period (1998-2006) was undertaken. Features evaluated were location, size, shape, marginal definition, internal echogenicity. A lipoma is a very common benign mass made up exclusively of fat cells. While the vast majority of lipomas are located just under the skin anywhere in the body, these lumpy masses may also develop in the abdomen and chest. About 16% of dogs are affected Middle-aged to geriatric dogs are most predisposed. Among these, obese adult female dogs are. Lipoma-like liposarcoma Liposarcoma, differentiated Inflammatory liposarcoma 8852/0 Fibromyxolipoma Myxolipoma 8852/3 Myxoid liposarcoma Myxoliposarcoma 8853/3 Round cell liposarcoma 8854/0 Pleomorphic lipoma 8854/3 Pleomorphic liposarcoma 8855/3 Mixed liposarcoma 8856/0 Intramuscular lipoma Infiltrating angiolipoma Infiltrating lipoma 8857/0.
Lipomas that lie just under the skin are harmless. But if at all the lipoma lies deep within the body (deep lipomas), these can cause pain and complications. In very rare cases, these become cancerous. The cancer affecting lipoma is called liposarcoma. If a lipoma is growing in size rapidly, it could be an early indicator of liposarcoma 10.1016/j.jamcollsurg.2013.06.003 10.1016/j.jamcollsurg.2013.06.003 2020-06-11 00:00:00 Lipomatous neoplasms are commonly encountered by the general surgeon as well as the surgical oncologist. Collectively, lipomatous neoplasms comprise half of all soft tissue tumors, but the individual histologic subtypes are diverse and range from the benign lipoma to the aggressive liposarcoma atypical lipoma: lipoma, occurring primarily in older men on the posterior neck, shoulders, and back, which is benign but microscopically atypical, containing giant cells with multiple overlapping nuclei forming a circle. Synonym(s): pleomorphic lipoma Every once in a great while, a fatty tumor turns out to be an infiltrative liposarcoma rather than a lipoma. (speakingforspot.com) Lipoma is the most familiar soft-tissue tumor. In this respect, the authors tried to define the correlation of soft tissue lipoma tumor cell and specific 2 immunohistologic markers, vascular endothelial growth.